Metabolomic and lipidomic approaches to identify biomarkers for bladder cancer and interstitial cystitis
- Authors
- Shahid, Muhammad; Yeon, Austin; Kim, Jayoung
- Issue Date
- Dec-2020
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- bladder cancer; interstitial cystitis; metabolomics; lipidomics; biomarkers
- Citation
- MOLECULAR MEDICINE REPORTS, v.22, no.6, pp.5003 - 5011
- Journal Title
- MOLECULAR MEDICINE REPORTS
- Volume
- 22
- Number
- 6
- Start Page
- 5003
- End Page
- 5011
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79638
- DOI
- 10.3892/mmr.2020.11627
- ISSN
- 1791-2997
- Abstract
- The discovery, introduction and clinical use of prognostic and diagnostic biomarkers has significantly improved outcomes for patients with various illnesses, including bladder cancer (BC) and other bladder-related diseases, such as benign bladder dysfunction and interstitial cystitis (IC). Several sensitive and noninvasive clinically relevant biomarkers for BC and IC have been identified. Metabolomic- and lipidomic-based biomarkers have notable clinical potential in improving treatment outcomes for patients with cancer; however, there are also some noted limitations. This review article provides a short and concise summary of the literature on metabolomic and lipidomic biomarkers for BC and IC, focusing on the possible clinical utility of profiling metabolic alterations in BC and IC.
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