Molecular insights into the development of hepatic metastases in colorectal cancer: a metastasis prediction study
- Authors
- Yang, J.; Kim, H.; Shin, K.; Nam, Y.; Heo, H. J.; Kim, G. H.; Hwang, B-Y; Kim, J.; Woo, S.; Choi, H. S.; Ko, D. S.; Lee, D.; Kim, Y. H.
- Issue Date
- Dec-2020
- Publisher
- VERDUCI PUBLISHER
- Keywords
- Colorectal cancer; Hepatic metastases; LASSO; Prognosis
- Citation
- EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, v.24, no.24, pp.12701 - 12708
- Journal Title
- EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Volume
- 24
- Number
- 24
- Start Page
- 12701
- End Page
- 12708
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79698
- DOI
- 10.26355/eurrev_202012_24168
- ISSN
- 1128-3602
- Abstract
- OBJECTIVE: Colorectal cancer is presently the third most commonly diagnosed cancer in the United States. In this study, we identified molecular differences between hepatic and non-hepatic metastases in colorectal cancer and evaluated their prognostic significance. MATERIALS AND METHODS: We downloaded primary data from the NCBI Gene Expression Omnibus (GSE6988, GSE62321, GSE50760, and GSE28722). To identify the molecular differences, we used the Significance Analysis of Microarray method. We selected nine prognostic genes (SYTL2, PTPLAD1, CDS1, RNF138, PIGR, WDR78, MYO7B, TSPAN3, and ATP5F1) with hepatic metastasis prediction score in colorectal cancer (hereafter referred to as LASSO Score). We confirmed the prognostic significance of the LASSO Score by using Kaplan-Meier survival analysis, multivariate analysis, the time-dependent area under the curve (AUC) of Uno's C-index, and the AUC of the receiver operating characteristic curve at 1-5 years. RESULTS: Survival analysis revealed that a high LASSO Score is associated with a poor prognosis in colorectal cancer patients with hepatic metastases (p = 0). Analysis of C-indices and AUC values from the receiver operating characteristic curve further supported this prediction by the LASSO Score. Multivariate analysis confirmed the prognostic significance of the LASSO Score (p = 1.13e-06). CONCLUSIONS: This study reveals the biological mechanisms underlying hepatic metastases in colorectal cancer and will help in developing targeted therapies for colorectal cancer.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79698)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.