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Anti-neuroinflammatory constituents from Sinomenium acutum rhizomes
- Authors
- Lee, Seung Young; Suh, Won Se; Cha, Joon Min; Moon, Eunjung; Ha, Sang Keun; Kim, Sun Yeou; Lee, Kang Ro
- Issue Date
- Sep-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Sinomenium acutum; Menispermaceae; Lignan; Neuroprotection; Anti-neuroinflammation
- Citation
- PHYTOCHEMISTRY LETTERS, v.17, pp.79 - 84
- Journal Title
- PHYTOCHEMISTRY LETTERS
- Volume
- 17
- Start Page
- 79
- End Page
- 84
- ISSN
- 1874-3900
- Abstract
- In our continuing search for bioactive constituents from Korean medicinal sources, an investigation of the Sinomenium acutum Rehder et Wilson rhizome afforded three new lignan derivatives (1-3) together with nine known compounds (4-12). The identification and structural elucidation of these new compounds were based on 1D and 2D-NMR (COSY, HMQC, HMBC and NOESY) and MS data. The absolute configurations were established based on the CD data. Nitric oxide production was evaluated in the BV-2 lipopolysaccharide-activated microglia cell line to investigate the anti-neuroinflammatory effects of the isolated compounds (1-12). (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)