Difference in Vitamin D Levels Between Children with Clostridioides difficile Enteritis and Those with Other Acute Infectious Enteritis
- Authors
- Sang Woo Park; Young June Lee; Eell Ryoo
- Issue Date
- Jan-2021
- Publisher
- 대한소아소화기영양학회
- Keywords
- Clostridioides difficile; Children; Vitamin D; Receptors; calcitriol
- Citation
- Pediatric Gastroenterology, Hepatology & Nutrition, v.24, no.1, pp.81 - 89
- Journal Title
- Pediatric Gastroenterology, Hepatology & Nutrition
- Volume
- 24
- Number
- 1
- Start Page
- 81
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79901
- DOI
- 10.5223/pghn.2021.24.1.81
- ISSN
- 2234-8646
- Abstract
- Purpose: A steady increase in Clostridioides difficile enteritis (CDE) has been reported recently. CDE is associated with intestinal dysbiosis, and vitamin D receptors are known to play an important role in this microbial imbalance as immunological regulators. We investigated the difference in vitamin D levels between children with CDE and those with other acute infectious enteritis.
Methods: This retrospective study was conducted on children below 18 years of age who visited the Gil hospital, underwent investigation to assess vitamin D levels, and had confirmed gastrointestinal infection between January 2015 and December 2018. Patients were divided into two groups: the “CDE group” (n=18) and the “other infectious enteritis group” (n=88); their clinical characteristics, other laboratory results, and vitamin D levels were analyzed.
Results: There was no difference in gender, age, and seasonal distributions between the CDE and other infectious enteritis groups. Other laboratory results were not significantly different between two groups, excluding serum albumin level (4.52±0.45 g/dL vs. 4.31±0.28 g/dL, p=0.011). The mean 25-hydroxy vitamin D level in the CDE group was higher than that in the control group (18.75±8.11 ng/mL vs. 14.50±6.79 ng/mL, p=0.021).
Conclusion: Vitamin D levels in the CDE group were lower than normal but higher than the other infectious enteritis group. These results suggested that CDE has a different mechanism or susceptibility associated with vitamin D in children, and even marginal changes in vitamin D levels can act as a risk factor for infection.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/79901)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.