Contribution of the Individual Small Intestinal alpha-Glucosidases to Digestion of Unusual alpha-Linked Glycemic Disaccharides
DC Field | Value | Language |
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dc.contributor.author | Lee, Byung-Hoo | - |
dc.contributor.author | Rose, David R. | - |
dc.contributor.author | Lin, Amy Hui-Mei | - |
dc.contributor.author | Quezada-Calvillo, Roberto | - |
dc.contributor.author | Nichols, Buford L. | - |
dc.contributor.author | Hamaker, Bruce R. | - |
dc.date.available | 2020-02-28T00:45:22Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08-24 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/7999 | - |
dc.description.abstract | The mammalian mucosal alpha-glucosidase complexes, maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI), have two catalytic subunits (N- and C-termini). Concurrent with the desire to modulate glycemic response, there has been a focus on di/oligosaccharides with unusual alpha-linkages that are digested to glucose slowly by these enzymes. Here, we look at disaccharides with various possible alpha-linkages and their hydrolysis. Hydrolytic properties of the maltose and sucrose isomers were determined using rat intestinal and individual recombinant alpha-glucosidases. The individual alpha-glucosidases had moderate to low hydrolytic activities on all alpha-linked disaccharides, except trehalose. Maltase (N-terminal MGAM) showed a higher ability to digest alpha-1,2 and alpha-1,3 disaccharides, as well as alpha-1,4, making it the most versatile in alpha-hydrolytic activity. These findings apply to the development of new glycemic oligosaccharides based on unusual alpha-linkages for extended glycemic response. It also emphasizes that mammalian mucosal alpha-glticosidases must be used in in-vitro assessment of digestion of such carbohydrates. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.subject | MALTASE-GLUCOAMYLASE ACTIVITY | - |
dc.subject | SUCRASE-ISOMALTASE | - |
dc.subject | STARCH DIGESTION | - |
dc.subject | SUBSTRATE BRAKE | - |
dc.subject | SUCROSE | - |
dc.subject | ISOMALTULOSE | - |
dc.subject | SPECIFICITY | - |
dc.subject | HYDROLYSIS | - |
dc.subject | PROTEIN | - |
dc.subject | INTOLERANCE | - |
dc.title | Contribution of the Individual Small Intestinal alpha-Glucosidases to Digestion of Unusual alpha-Linked Glycemic Disaccharides | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000382179000012 | - |
dc.identifier.doi | 10.1021/acs.jafc.6b01816 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.33, pp.6487 - 6494 | - |
dc.identifier.scopusid | 2-s2.0-84983604516 | - |
dc.citation.endPage | 6494 | - |
dc.citation.startPage | 6487 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 33 | - |
dc.contributor.affiliatedAuthor | Lee, Byung-Hoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | alpha-glucosidases | - |
dc.subject.keywordAuthor | carbohydrate digestion | - |
dc.subject.keywordAuthor | disaccharides | - |
dc.subject.keywordAuthor | glycemic | - |
dc.subject.keywordAuthor | slowly digestible carbohydrates | - |
dc.subject.keywordPlus | MALTASE-GLUCOAMYLASE ACTIVITY | - |
dc.subject.keywordPlus | SUCRASE-ISOMALTASE | - |
dc.subject.keywordPlus | STARCH DIGESTION | - |
dc.subject.keywordPlus | SUBSTRATE BRAKE | - |
dc.subject.keywordPlus | SUCROSE | - |
dc.subject.keywordPlus | ISOMALTULOSE | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | HYDROLYSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INTOLERANCE | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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