Deciphering the antitussive, expectorant, and anti- inflammatory potentials of Shashamkyeongok-go and their phytochemical attributes: In vivo appraisal in ICR mice
DC Field | Value | Language |
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dc.contributor.author | Hu, Jin-Ryul | - |
dc.contributor.author | Jung, Chul-Jong | - |
dc.contributor.author | Ku, Seong-Min | - |
dc.contributor.author | Jung, Dae-Hwa | - |
dc.contributor.author | Ku, Sae-Kwang | - |
dc.contributor.author | Mohibbullah, M. | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.contributor.author | Choi, Jae-Suk | - |
dc.date.available | 2021-03-02T00:40:32Z | - |
dc.date.created | 2021-02-22 | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80083 | - |
dc.description.abstract | In this paper, we hypothesized that ShashamKyeongok-go (SKOG) is a mixed preparation of Adenophorae Radix powder (AR) and Kyeongok-go (KOG). SKOG may be served as a novel preventive and/or therapeutic agent for various respiratory diseases. SKOG were orally administered to ICR mice at 400, 200, and 100 mg/kg once a day for 11 days to examine antitussive, expectorant, and anti-inflammatory effects. The NH4OH exposure-induced allergic acute inflammation with coughing responses was dose-dependently and significantly (p < 0.01) inhibited by pretreatment with SKOG at doses of 400, 200, and 100 mg/kg. With these concentrations of SKOG, the thickness of intrapulmonary secondary bronchus mucosa and the number of periodic acid Schiff stain-positive mucous-producing cells were significantly (p < 0.05 or p < 0.01) increased, as a result of the increased amount of phenol red secretion. Subsequently, SKOG showed significant (p < 0.01) anti-inflammatory activities as characterized by reducing the effects of xylene-induced increases of ear weight, thickness of total ear and ear dermis, and number of infiltrated inflammatory cells in the ear dermis, in a dose-dependent manner. These results supported that SKOG might have potential therapeutic effects to be used as an antitussive, expectorant, and anti-inflammatory agents in the prevention or treatment of chronic bronchitis and asthma. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | APPLIED SCIENCES-BASEL | - |
dc.title | Deciphering the antitussive, expectorant, and anti- inflammatory potentials of Shashamkyeongok-go and their phytochemical attributes: In vivo appraisal in ICR mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000614999800001 | - |
dc.identifier.doi | 10.3390/app11031349 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.11, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100556425 | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Adenophorae radix | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Antitussive effects | - |
dc.subject.keywordAuthor | Expectorant effects | - |
dc.subject.keywordAuthor | Kyeongok-go | - |
dc.subject.keywordAuthor | Shashamkyeongok-go | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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