Deciphering the antitussive, expectorant, and anti- inflammatory potentials of Shashamkyeongok-go and their phytochemical attributes: In vivo appraisal in ICR mice
- Authors
- Hu, Jin-Ryul; Jung, Chul-Jong; Ku, Seong-Min; Jung, Dae-Hwa; Ku, Sae-Kwang; Mohibbullah, M.; Lee, Hae-Jeung; Choi, Jae-Suk
- Issue Date
- Feb-2021
- Publisher
- MDPI
- Keywords
- Adenophorae radix; Anti-inflammation; Antitussive effects; Expectorant effects; Kyeongok-go; Shashamkyeongok-go
- Citation
- APPLIED SCIENCES-BASEL, v.11, no.3
- Journal Title
- APPLIED SCIENCES-BASEL
- Volume
- 11
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80083
- DOI
- 10.3390/app11031349
- ISSN
- 2076-3417
- Abstract
- In this paper, we hypothesized that ShashamKyeongok-go (SKOG) is a mixed preparation of Adenophorae Radix powder (AR) and Kyeongok-go (KOG). SKOG may be served as a novel preventive and/or therapeutic agent for various respiratory diseases. SKOG were orally administered to ICR mice at 400, 200, and 100 mg/kg once a day for 11 days to examine antitussive, expectorant, and anti-inflammatory effects. The NH4OH exposure-induced allergic acute inflammation with coughing responses was dose-dependently and significantly (p < 0.01) inhibited by pretreatment with SKOG at doses of 400, 200, and 100 mg/kg. With these concentrations of SKOG, the thickness of intrapulmonary secondary bronchus mucosa and the number of periodic acid Schiff stain-positive mucous-producing cells were significantly (p < 0.05 or p < 0.01) increased, as a result of the increased amount of phenol red secretion. Subsequently, SKOG showed significant (p < 0.01) anti-inflammatory activities as characterized by reducing the effects of xylene-induced increases of ear weight, thickness of total ear and ear dermis, and number of infiltrated inflammatory cells in the ear dermis, in a dose-dependent manner. These results supported that SKOG might have potential therapeutic effects to be used as an antitussive, expectorant, and anti-inflammatory agents in the prevention or treatment of chronic bronchitis and asthma. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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