Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Jung, Okkeun | - |
dc.contributor.author | Lee, Jongsung | - |
dc.contributor.author | Lee, Yu Jin | - |
dc.contributor.author | Yun, Jung-Mi | - |
dc.contributor.author | Son, Young-Jin | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.contributor.author | Ryou, Chongsuk | - |
dc.contributor.author | Lee, Sang Yeol | - |
dc.date.available | 2020-02-28T00:45:34Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8010 | - |
dc.description.abstract | Timosaponin AIII (TAIII) is a type of steroidal saponins isolated from Anemarrhena asphodeloides. It was known to improve learning and memory deficits through anti-inflammatory effects. TAIII was also reported to induce autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells and inhibit the growth of human colorectal cancer cells, thus regarded as a potential candidate for anti-cancer agent. In this study, we verified apoptosis-inducing and cell-cycle-arresting effects of TAIII in A549 human non-small-cell lung cancer (NSCLC) cells. Then, we report that TAIII suppresses migration and invasion of A549 human NSCLC cells. We propose that two matrix metalloproteinases (MMPs), MMP-2 and MMP-9, which are well known to be involved in cancer-metastasis, are attenuated by the treatment of TAIII. TAIII exerts its suppressive effects on MMP-2 and MMP-9 via inhibitions of ERK1/2, Src/FAK and beta-catenin signalings which are closely related with the regulations of MMP-2 and MMP-9. (C) 2016 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | ANEMARRHENA-ASPHODELOIDES | - |
dc.subject | SUPPRESSES MIGRATION | - |
dc.subject | METASTASIS | - |
dc.subject | APOPTOSIS | - |
dc.subject | MEMORY | - |
dc.subject | BUNGE | - |
dc.subject | MYC | - |
dc.title | Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000380574400024 | - |
dc.identifier.doi | 10.1016/j.bmcl.2016.07.004 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.16, pp.3963 - 3967 | - |
dc.identifier.scopusid | 2-s2.0-84979561977 | - |
dc.citation.endPage | 3967 | - |
dc.citation.startPage | 3963 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 26 | - |
dc.citation.number | 16 | - |
dc.contributor.affiliatedAuthor | Jung, Okkeun | - |
dc.contributor.affiliatedAuthor | Lee, Yu Jin | - |
dc.contributor.affiliatedAuthor | Lee, Sang Yeol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Timosaponin AIII | - |
dc.subject.keywordAuthor | ERK1/2 | - |
dc.subject.keywordAuthor | Src | - |
dc.subject.keywordAuthor | FAK | - |
dc.subject.keywordAuthor | Metastasis | - |
dc.subject.keywordAuthor | Matrix metalloproteinases | - |
dc.subject.keywordAuthor | Human non-small-cell lung cancer | - |
dc.subject.keywordPlus | ANEMARRHENA-ASPHODELOIDES | - |
dc.subject.keywordPlus | SUPPRESSES MIGRATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | BUNGE | - |
dc.subject.keywordPlus | MYC | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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