Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and beta-catenin signaling pathways
- Authors
- Jung, Okkeun; Lee, Jongsung; Lee, Yu Jin; Yun, Jung-Mi; Son, Young-Jin; Cho, Jae Youl; Ryou, Chongsuk; Lee, Sang Yeol
- Issue Date
- 15-Aug-2016
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Timosaponin AIII; ERK1/2; Src; FAK; Metastasis; Matrix metalloproteinases; Human non-small-cell lung cancer
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.16, pp.3963 - 3967
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 26
- Number
- 16
- Start Page
- 3963
- End Page
- 3967
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8010
- DOI
- 10.1016/j.bmcl.2016.07.004
- ISSN
- 0960-894X
- Abstract
- Timosaponin AIII (TAIII) is a type of steroidal saponins isolated from Anemarrhena asphodeloides. It was known to improve learning and memory deficits through anti-inflammatory effects. TAIII was also reported to induce autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells and inhibit the growth of human colorectal cancer cells, thus regarded as a potential candidate for anti-cancer agent. In this study, we verified apoptosis-inducing and cell-cycle-arresting effects of TAIII in A549 human non-small-cell lung cancer (NSCLC) cells. Then, we report that TAIII suppresses migration and invasion of A549 human NSCLC cells. We propose that two matrix metalloproteinases (MMPs), MMP-2 and MMP-9, which are well known to be involved in cancer-metastasis, are attenuated by the treatment of TAIII. TAIII exerts its suppressive effects on MMP-2 and MMP-9 via inhibitions of ERK1/2, Src/FAK and beta-catenin signalings which are closely related with the regulations of MMP-2 and MMP-9. (C) 2016 Elsevier Ltd. All rights reserved.
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