Vitamin D levels are not predictors of survival in a clinic population of patients with ALS
DC Field | Value | Language |
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dc.contributor.author | Yang, Jiwon | - |
dc.contributor.author | Park, Jin-Seok | - |
dc.contributor.author | Oh, Ki-Wook | - |
dc.contributor.author | Oh, Seong-il | - |
dc.contributor.author | Park, Hyeon-Mi | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.date.available | 2020-02-28T00:45:36Z | - |
dc.date.created | 2020-02-07 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8012 | - |
dc.description.abstract | Objective: This study aimed to measure serum 25-hydroxyvitamin D[25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. Methods: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10 ng/ml and >= 10 ng/ml. Results: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan-Meier analysis with log-rank test, the survival rates of patients without (10 ng/ml) and of those with severe vitamin D deficiency (<10 ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. Conclusions: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.title | Vitamin D levels are not predictors of survival in a clinic population of patients with ALS | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000381167600018 | - |
dc.identifier.doi | 10.1016/j.jns.2016.05.007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, v.367, pp.83 - 88 | - |
dc.identifier.scopusid | 2-s2.0-84971641408 | - |
dc.citation.endPage | 88 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 367 | - |
dc.contributor.affiliatedAuthor | Yang, Jiwon | - |
dc.contributor.affiliatedAuthor | Park, Hyeon-Mi | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Amyotrophic lateral sclerosis | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Bone density | - |
dc.subject.keywordAuthor | Survival | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | PROTECTIVE FACTOR | - |
dc.subject.keywordPlus | D DEFICIENCY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | DYSLIPIDEMIA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | BONE | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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