Vitamin D levels are not predictors of survival in a clinic population of patients with ALS
- Authors
- Yang, Jiwon; Park, Jin-Seok; Oh, Ki-Wook; Oh, Seong-il; Park, Hyeon-Mi; Kim, Seung Hyun
- Issue Date
- Aug-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Amyotrophic lateral sclerosis; Vitamin D; Bone density; Survival
- Citation
- JOURNAL OF THE NEUROLOGICAL SCIENCES, v.367, pp.83 - 88
- Journal Title
- JOURNAL OF THE NEUROLOGICAL SCIENCES
- Volume
- 367
- Start Page
- 83
- End Page
- 88
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8012
- DOI
- 10.1016/j.jns.2016.05.007
- ISSN
- 0022-510X
- Abstract
- Objective: This study aimed to measure serum 25-hydroxyvitamin D[25(OH)D] concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival. Methods: We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10 ng/ml and >= 10 ng/ml. Results: There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan-Meier analysis with log-rank test, the survival rates of patients without (10 ng/ml) and of those with severe vitamin D deficiency (<10 ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors. Conclusions: In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients. (C) 2016 Elsevier B.V. All rights reserved.
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