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One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction
- Authors
- Hyun, Soonsil; Park, Namjoon; Nam, So Hee; Cheon, Dae Hee; Lee, Yan; Lim, Hyun-Suk; Yu, Jaehoon
- Issue Date
- 7-Mar-2021
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- CHEMICAL COMMUNICATIONS, v.57, no.19, pp.2388 - 2391
- Journal Title
- CHEMICAL COMMUNICATIONS
- Volume
- 57
- Number
- 19
- Start Page
- 2388
- End Page
- 2391
- ISSN
- 1359-7345
- Abstract
- In an effort designed to discover superior inhibitors of cyclophilin D (CypD), we identified and screened members of a one-bead-one-compound (OBOC) library of cyclic peptoid analogues of cyclosporin A (CsA). The results show that the one member of this cyclic peptoid family, I11, inhibits mitochondrial membrane potential changes mediated by CypD.
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