(-)-Leucophyllone, a Tirucallane Triterpenoid from Cornus walteri, Enhances Insulin Secretion in INS-1 Cells
- Authors
- Lee, Dahae; Kim, Ki Hyun; Jang, Taesu; Kang, Ki Sung
- Issue Date
- Mar-2021
- Publisher
- MDPI
- Keywords
- (-)-leucophyllone; Cornaceae; Cornus walteri; Glucose-stimulated insulin secretion; PDX1
- Citation
- PLANTS-BASEL, v.10, no.3
- Journal Title
- PLANTS-BASEL
- Volume
- 10
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80698
- DOI
- 10.3390/plants10030431
- ISSN
- 2223-7747
- Abstract
- Phytochemical examination of the MeOH extract from the stems and stem bark of Cornus walteri (Cornaceae) led to the isolation and verification of a tirucallane triterpenoid, (-)-leucophyllone, as a major component. Its structure was elucidated using NMR spectroscopy and liquid chromatography–mass spectrometry. The effect of (-)-leucophyllone on insulin secretion in INS-1 cells was investigated. (-)-Leucophyllone increased glucose-stimulated insulin secretion (GSIS) at concentrations showing no cytotoxic effect in rat INS-1 pancreatic β-cells. Moreover, we attempted to determine the mechanism of action of (-)-leucophyllone in the activation of insulin receptor sub-strate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and pancreatic and duodenal homeobox-1 (PDX-1). Treatment of INS-1 cells with (-)-leucophyllone markedly increased the expression of these proteins. Our findings indicate the potential of (-)-leucophyllone as an antidiabetic agent. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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