The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled TrialThe Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled Trial
- Other Titles
- The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled Trial
- Authors
- Youn HyunChul; Lee Kang Joon; Kim Shin-Gyeom; Cho Seong-Jin; Kim Woo Jung; Lee Won Joon; Hwang Jae Yeon; Han Changsu; Shin Cheolmin; Jung Han-yong
- Issue Date
- Mar-2021
- Publisher
- 대한신경정신의학회
- Keywords
- Alzheimer’s dementia; Memantine; Acetylcholinesterase inhibitors; Behavioral and psychological symptoms of dementia; Disinhibition; Neuropsychiatric inventory
- Citation
- PSYCHIATRY INVESTIGATION, v.18, no.3, pp.233 - 240
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 18
- Number
- 3
- Start Page
- 233
- End Page
- 240
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80821
- DOI
- 10.30773/pi.2020.0329
- ISSN
- 1738-3684
- Abstract
- Objective This study aimed to investigate treatment effects of combination therapy of memantine and acetylcholinesterase inhibitors (AchEIs) compared with AchEIs alone on behavioral and psychological symptoms of dementia (BPSD) in patients with moderate Alzheimer’s dementia (AD).Methods This was a 12-week, double-blind, randomized, placebo-controlled trial. A total of 148 patients with moderate AD participated in this study. Mini-Mental State Examination, Neuropsychiatric Inventory (NPI), Clinician’s Interview-Based Impression of Change plus caregiver input, Gottfries–Bråne–Steen Scale, and Zarit Burden Interview were used as assessment scales.Results There were no significant differences in age, sex, or education between AChEIs alone and combination groups. The combination group showed significantly more improvement of NPI-disinhibition score (0.76±2.15) than the AChEIs alone group (-0.14±1.71) after 12 weeks.Conclusion Our findings suggest that the combination therapy of memantine and AchEIs might be a beneficial option for reducing disinhibition symptoms of patients with moderate AD compared with AchEIs alone. We believe that clinicians need to consider additional memantine treatment when patients with moderate AD complain disinhibition symptom. A larger clinical trial is needed to further determine the efficacy and advantages of such combination therapy of memantine and AchEIs for treating BPSD of patients with moderate AD.
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