Clinical and Virologic Effectiveness of Remdesivir Treatment for Severe Coronavirus Disease 2019 (COVID-19) in Korea: a Nationwide Multicenter Retrospective Cohort Study
- Authors
- Joo Eun-Jeong; Ko Jae-Hoon; Kim Seong Eun; Kang Seung-Ji; Baek Ji Hyeon; Heo Eun Young; Shi Hye Jin; Eom Joong Sik; Choe Pyoeng Gyun; Bae Seongman; Ra Sang Hyun; Kim Da Young; Kim Baek-Nam; Kang Yu Min; Kim Ji Yeon; Chung Jin-Won; Chang Hyun-Ha; Bae Sohyun; Cheon Shinhyea; Park Yoonseon; Choi Heun; Lee Eunjung; Lee Bo young; Park Jung Wan; Sohn Yujin; Heo Jung Yeon; Kim Sung-Han; Peck Kyong Ran
- Issue Date
- Mar-2021
- Publisher
- 대한의학회
- Keywords
- Remdesivir; Severe; COVID-19; Clinical; Virologic
- Citation
- Journal of Korean Medical Science, v.36, no.11, pp.1 - 13
- Journal Title
- Journal of Korean Medical Science
- Volume
- 36
- Number
- 11
- Start Page
- 1
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80862
- DOI
- 10.3346/jkms.2021.36.e83
- ISSN
- 1011-8934
- Abstract
- Background: Remdesivir is widely used for the treatment of coronavirus disease 2019 (COVID-19), but controversies regarding its efficacy still remain.
Methods: A retrospective cohort study was conducted to evaluate the effect of remdesivir on clinical and virologic outcomes of severe COVID-19 patients from June to July 2020. Primary clinical endpoints included clinical recovery, additional mechanical ventilator (MV) support, and duration of oxygen or MV support. Viral load reduction by hospital day (HD) 15 was evaluated by calculating changes in cycle threshold (Ct) values.
Results: A total of 86 severe COVID-19 patients were evaluated including 48 remdesivir-treated patients. Baseline characteristics were not significantly different between the two groups. Remdesivir was administered an average of 7.42 days from symptom onset. The proportions of clinical recovery of the remdesivir and supportive care group at HD 14 (56.3% and 39.5%) and HD 28 (87.5% and 78.9%) were not statistically different. The proportion of patients requiring MV support by HD 28 was significantly lower in the remdesivir group than in the supportive care group (22.9% vs. 44.7%, P = 0.032), and MV duration was significantly shorter in the remdesivir group (average, 1.97 vs. 5.37 days; P = 0.017). Analysis of upper respiratory tract specimens demonstrated that increases of Ct value from HD 1–5 to 11–15 were significantly greater in the remdesivir group than the supportive care group (average, 10.19 vs. 5.36; P = 0.007), and the slope of the Ct value increase was also significantly steeper in the remdesivir group (average, 5.10 vs. 2.68; P = 0.007).
Conclusion: The remdesivir group showed clinical and virologic benefit in terms of MV requirement and viral load reduction, supporting remdesivir treatment for severe COVID-19.
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