Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammation
DC Field | Value | Language |
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dc.contributor.author | Kang, Jinjoo | - |
dc.contributor.author | Lee, Soyoung | - |
dc.contributor.author | Kim, Namkyung | - |
dc.contributor.author | Dhakal, Hima | - |
dc.contributor.author | Choi, Young-Ae | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.contributor.author | Kim, Sang-Hyun | - |
dc.date.available | 2021-04-29T00:35:14Z | - |
dc.date.created | 2021-03-02 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80865 | - |
dc.description.abstract | Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects 10–20% of the world's population. Therefore, the discovery of drugs for the treatment of AD is important for human health. Hispidulin (HPD; also known as scutellarein 6-methyl ether or dinatin) is a natural flavone that exerts anti-inflammatory effects. In the present study, the effectiveness of HPD on AD-like skin inflammation was investigated. We used a mouse AD model through repeated exposure of mice to 2,4-dinitrochlorobenzene and house dust mite extract (Dermatophagoides farinae extract, DFE) to the ears. In addition, tumor necrosis factor-α and interferon-γ-activated keratinocytes (HaCaT cells) were used to investigate the underlying mechanism of HPD action. Oral administration of HPD alleviated AD-like skin inflammations: it reduced ear thickness; serum immunoglobulin (Ig)E, DFE-specific IgE, and IgG2a levels; and inflammatory cell infiltration. HPD reduced the expression of pro-inflammatory cytokines and chemokines through inhibition of signal transducer and activator of transcription 1 nuclear factor-κB in HaCaT cells. Taken together, these results suggest that HPD could be a potential drug candidate for the treatment of AD. © 2021 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.title | Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000634759700007 | - |
dc.identifier.doi | 10.1016/j.biopha.2021.111359 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, v.137 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85100999204 | - |
dc.citation.title | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.citation.volume | 137 | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Hispidulin | - |
dc.subject.keywordAuthor | House dust mite | - |
dc.subject.keywordAuthor | Keratinocytes | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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