Hispidulin alleviates 2,4-dinitrochlorobenzene and house dust mite extract-induced atopic dermatitis-like skin inflammation
- Authors
- Kang, Jinjoo; Lee, Soyoung; Kim, Namkyung; Dhakal, Hima; Choi, Young-Ae; Kwon, Taeg Kyu; Khang, Dongwoo; Kim, Sang-Hyun
- Issue Date
- May-2021
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Atopic dermatitis; Hispidulin; House dust mite; Keratinocytes
- Citation
- BIOMEDICINE & PHARMACOTHERAPY, v.137
- Journal Title
- BIOMEDICINE & PHARMACOTHERAPY
- Volume
- 137
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80865
- DOI
- 10.1016/j.biopha.2021.111359
- ISSN
- 0753-3322
- Abstract
- Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects 10–20% of the world's population. Therefore, the discovery of drugs for the treatment of AD is important for human health. Hispidulin (HPD; also known as scutellarein 6-methyl ether or dinatin) is a natural flavone that exerts anti-inflammatory effects. In the present study, the effectiveness of HPD on AD-like skin inflammation was investigated. We used a mouse AD model through repeated exposure of mice to 2,4-dinitrochlorobenzene and house dust mite extract (Dermatophagoides farinae extract, DFE) to the ears. In addition, tumor necrosis factor-α and interferon-γ-activated keratinocytes (HaCaT cells) were used to investigate the underlying mechanism of HPD action. Oral administration of HPD alleviated AD-like skin inflammations: it reduced ear thickness; serum immunoglobulin (Ig)E, DFE-specific IgE, and IgG2a levels; and inflammatory cell infiltration. HPD reduced the expression of pro-inflammatory cytokines and chemokines through inhibition of signal transducer and activator of transcription 1 nuclear factor-κB in HaCaT cells. Taken together, these results suggest that HPD could be a potential drug candidate for the treatment of AD. © 2021
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