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Cited 27 time in webofscience Cited 28 time in scopus
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Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice

Authors
Oh, Yoon SinSeo, Eun-HuiLee, Young-SunCho, Sung ChunJung, Hye SeungPark, Sang ChulJun, Hee-Sook
Issue Date
21-Jul-2016
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.11, no.7
Journal Title
PLOS ONE
Volume
11
Number
7
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8095
DOI
10.1371/journal.pone.0159689
ISSN
1932-6203
Abstract
Type 2 diabetes is caused by both insulin resistance and relative insulin deficiency. To investigate age-related changes in glucose metabolism and development of type 2 diabetes, we compared glucose homeostasis in different groups of C57BL/6J mice ranging in age from 4 months to 20 months (4, 8, 12, 16 and 20 months). Interestingly, we observed that non-fasting glucose levels were not significantly changed, but glucose tolerance gradually increased by 20 months of age, whereas insulin sensitivity declined with age. We found that the size of islets and glucose-stimulated insulin secretion increased with aging. However, mRNA expression of pancreatic and duodenal homeobox 1 and granuphilin was decreased in islets of older mice compared with that of 4-month-old mice. Serum calcium (Ca2+) levels were significantly decreased at 12, 20 and 28 months of age compared with 4 months and calcium sensing receptor (CaSR) mRNA expression in the islets significantly increased with age. An extracellular calcium depletion agent upregulated CaSR mRNA expression and consequently enhanced insulin secretion in INS-1 cells and mouse islets. In conclusion, we suggest that decreased Ca2+ levels and increased CaSR expression might be involved in increased insulin secretion to compensate for insulin resistance in aged mice.
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