Phytochemicals against anti-diabetic complications: targeting the advanced glycation end product signaling pathway
- Authors
- Parveen, Amna; Sultana, Razia; Lee, Seung Min; Kim, Tae Hun; Kim, Sun Yeou
- Issue Date
- Apr-2021
- Publisher
- Pharmaceutical Society of Korea
- Keywords
- Advanced glycation end products; Coronary artery disease; Diabetes; Nitric oxide; Phytochemicals; Reactive oxygen species; Receptor for advanced end product glycation
- Citation
- Archives of Pharmacal Research, v.44, no.4, pp.378 - 401
- Journal Title
- Archives of Pharmacal Research
- Volume
- 44
- Number
- 4
- Start Page
- 378
- End Page
- 401
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80967
- DOI
- 10.1007/s12272-021-01323-9
- ISSN
- 0253-6269
- Abstract
- The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators, including the receptor for advanced glycation end products, high mobility group box 1, glyoxalase 1, nuclear factor-kappa B, tumor necrosis factor-α, chronic unpredictable stress, reactive oxygen species, and inflammatory cytokines, which interact with AGE signaling and control diabetes, modulating these interacting modulators. The progression of diabetes, as well as related complications, can be controlled and treated. Natural products rich in bioactive constituents can interact with AGEs and their related mediators through various signaling cascades, thereby controlling and preventing the progression of diabetes. This review provides a deeper assessment of the signaling pathway, interactions between phytochemicals and AGEs, and its mediators, to develop a multifold therapeutic approach to prevent and treat diabetes and its related complications. © 2021, The Pharmaceutical Society of Korea.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/80967)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.