Assessment of the anti-metastatic properties of sanguiin H-6 in HUVECs and MDA-MB-231 human breast cancer cells
- Authors
- Park, Eun-Hwa; Park, Jun Yeon; Yoo, Hwa-Seung; Yoo, Jeong-Eun; Lee, Hye Lim
- Issue Date
- 15-Jul-2016
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Sanguiin H-6; Metastasis; HUVEC; Breast cancer; VEGF
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.14, pp.3291 - 3294
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 26
- Number
- 14
- Start Page
- 3291
- End Page
- 3294
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8099
- DOI
- 10.1016/j.bmcl.2016.05.050
- ISSN
- 0960-894X
- Abstract
- The anti-metastatic properties of sanguiin H-6 were examined in human umbilical vein vascular endothelial cells (HUVECs) and MDA-MB-231 human breast cancer cells. In HUVECs, sanguiin H-6 inhibited the density of migrated cells compared to that observed after treatment with the vehicle. In addition, sanguiin H-6 at a concentration of 6.25 mu M significantly blocked tube formation. Treatment with up to 25 mu M sanguiin H-6 had no effect on MDA-MB-231 cells, whereas treatment with 200 mu M sanguiin H-6 decreased cell viability. Sanguiin H-6 significantly decreased the expression levels of vascular endothelial growth factor (VEGF), phosphorylated Akt, and extracellular signal-regulated kinase 1/2 (ERK1/2) in MDA-MB-231 cells. These findings suggest that sanguiin H-6 is potentially useful as an anti-metastatic agent. (C) 2016 Elsevier Ltd. All rights reserved.
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