Energetically Biased DNA Motor Containing a Thermodynamically Stable Partial Strand Displacement State
- Authors
- Landon, Preston B.; Lee, Joon; Hwang, Michael Taeyoung; Mo, Alexander H.; Zhang, Chen; Neuberger, Anthony; Meckes, Brian; Gutierrez, Jose J.; Glinsky, Gennadi; Lal, Ratnesh
- Issue Date
- Nov-2014
- Publisher
- AMER CHEMICAL SOC
- Citation
- LANGMUIR, v.30, no.46, pp.14073 - 14078
- Journal Title
- LANGMUIR
- Volume
- 30
- Number
- 46
- Start Page
- 14073
- End Page
- 14078
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81338
- DOI
- 10.1021/la503711g
- ISSN
- 0743-7463
- Abstract
- Current work in tuning DNA kinetics has focused on changing toehold lengths and DNA concentrations. However, kinetics can also be improved by enhancing the completion probability of the strand displacement process. Here, we execute this strategy by creating a toehold DNA motor device with the inclusion of a synthetic nucleotide, inosine, at selected sites. Furthermore, we found that the energetic bias can be tuned such that the device can stay in a stable partially displaced state. This work demonstrates the utility of energetic biases to change DNA strand displacement kinetics and introduces a complementary strategy to the existing designs.
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Collections - 바이오나노대학 > 바이오나노학과 > 1. Journal Articles
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