Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults
- Authors
- Kwak, Jung Hyun; Choi, Yoon-Hyeong
- Issue Date
- 11-May-2021
- Publisher
- Nature Research
- Citation
- Scientific Reports, v.11, no.1, pp.9989
- Journal Title
- Scientific Reports
- Volume
- 11
- Number
- 1
- Start Page
- 9989
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81388
- DOI
- 10.1038/s41598-021-88855-8
- ISSN
- 2045-2322
- Abstract
- High pulse pressure (PP) is a valid indicator of arterial stiffness. Many studies have reported that vitamin D concentration is inversely associated with vascular stiffening. This association may differ depending on sex and body mass index (BMI). This study investigated the associations between vitamin D and PP and evaluated whether these associations differ according to sex and BMI, using data for individuals aged ≥ 50 years from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were used as biomarkers of vitamin D levels. High PP was defined as ≥ 60 mmHg. Total 25(OH)D concentrations were dose-dependently associated with lower odds ratios (ORs) for high PP (p-trend = 0.01), after controlling for sociodemographic, behavioral, and dietary factors. When stratified by sex, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in females, but not in males. When stratified by BMI, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in non-overweight subjects, but not in overweight subjects. Improving the vitamin D status could delay elevation of PP and vascular stiffening in female and non-overweight subjects.
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