Treatment strategies targeting specific genetic etiologies in epilepsy
- Authors
- Kim, Hyo Jeong; Kang, Hoon-Chul
- Issue Date
- Jun-2021
- Publisher
- 대한의학유전학회
- Keywords
- Epilepsy; Genetics; Precision medicine
- Citation
- Journal of Genetic Medicine, v.18, no.1, pp.8 - 15
- Journal Title
- Journal of Genetic Medicine
- Volume
- 18
- Number
- 1
- Start Page
- 8
- End Page
- 15
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81403
- DOI
- 10.5734/JGM.2021.18.1.8
- ISSN
- 1226-1769
- Abstract
- Recent genetic advances allow for identification of the genetic etiologies of epilepsy within individual patients earlier and more frequently than ever. Specific targeted treatments have emerged from improvements in understanding of the underlying epileptogenic pathophysiology. These targeted treatment strategies include modifications of ion channels or other cellular receptors and their function, mechanistic target of rapamycin signaling pathways, and substitutive therapies in hereditary metabolic epilepsies. In this review, we explore targeted treatments based on underlying pathophysiologic mechanisms in specific genetic epilepsies.
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Collections - 의과대학 > 의학과 > 1. Journal Articles
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