Identification of bioactive compounds from mulberry enhancing glucose-stimulated insulin secretion
- Authors
- Lee, Dahae; Kim, Ki Hyun; Jang, Tae Su; Kang, Ki Sung
- Issue Date
- 1-Jul-2021
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- AKT; Insulin; Morus alba; PDX-1; PI3K
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.43
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 43
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81489
- DOI
- 10.1016/j.bmcl.2021.128096
- ISSN
- 0960-894X
- Abstract
- Previously, we isolated six heterocyclic compounds (1–6) from the fruits of mulberry trees (Morus alba L.) and determined that loliolide affords rat pancreatic islet β-cell (INS-1) protection against streptozotocin‑induced cytotoxicity. In the present study, we further investigated the effect of the six heterocyclic compounds (1–6) on glucose-stimulated insulin secretion (GSIS) in INS-1 cells. Among them, (R)‑5‑hydroxypyrrolidin‑2‑one (1) and indole (6) increased GSIS without inducing cytotoxicity. Additionally, compounds 1 and 6 enhanced the phosphorylation of total insulin receptor substrate-2, phosphatidylinositol 3-kinase, and Akt, and activated pancreatic and duodenal homeobox-1, which play a crucial role in β-cell functions related to insulin secretion. Collectively, these findings indicate that (R)‑5‑hydroxypyrrolidin‑2‑one (1) and indole (6), isolated from M. alba fruits, may be beneficial in managing type 2 diabetes. © 2021 Elsevier Ltd
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