Retrospective analysis of current guidelines for hepatocellular carcinoma diagnosis on gadoxetic acid-enhanced MRI in at-risk patients
- Authors
- Park, So Hyun; Shim, Young Sup; Kim, Bohyun; Kim, So Yeon; Kim, Yun Soo; Huh, Jimi; Park, Ji Hyun; Kim, Kyung Won; Lee, Seung Soo
- Issue Date
- Jul-2021
- Publisher
- SPRINGER
- Keywords
- Hepatocellular carcinoma; Liver; Magnetic resonance imaging; Guideline
- Citation
- EUROPEAN RADIOLOGY, v.31, no.7, pp.4751 - 4763
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 31
- Number
- 7
- Start Page
- 4751
- End Page
- 4763
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81514
- DOI
- 10.1007/s00330-020-07577-z
- ISSN
- 0938-7994
- Abstract
- Objective To evaluate and compare the diagnostic performance of the updated HCC guidelines using gadoxetic acid-enhanced MRI. Methods In this study, patients at risk of HCC who underwent gadoxetic acid-enhanced MRI following US/CT surveillance were retrospectively recruited from 3 centers. Three radiologists independently evaluated hepatic nodule imaging features relevant to the diagnostic criteria outlined in each guideline. Per-lesion sensitivity, specificity, and accuracy were compared between guidelines using logistic regression with a generalized estimating equation. Inter-observer agreements on imaging features were determined using Fless kappa statistics. Results Altogether, 447 nodules (310 HCCs, 20 combined hepatocellular-cholangiocarcinomas, 2 cholangiocarcinomas, and 115 benign entities) measuring 1-3 cm from 386 patients were assessed. The KLCA-NCC and APASL guidelines showed the highest sensitivity (82.3-90.6%, p < .001) and accuracy (83.9-88.6%) among the five guidelines. The OPTN/UNOS guideline showed the highest specificity (94.9-97.1%), followed by the AASLD/LI-RADS, EASL, KLCA-NCC, and APASL guidelines, with significant difference only with the APASL guideline. The diagnostic performance of the updated AASLD/LI-RADS and EASL guidelines and of the KLCA-NCC and APASL guidelines was comparable (p > .05). Inter-observer agreement was substantial to almost perfect (kappa = 0.73-0.87). Conclusions For the diagnosis of HCC using gadoxetic acid-enhanced MRI, the KLCA-NCC and APASL guidelines showed the highest sensitivity and accuracy. The OPTN/UNOS guideline showed the highest specificity. Acknowledging their relative strengths and weaknesses could help adapt the diagnostic criteria according to the clinical context.
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