4,6 '-Anhydrooxysporidinone from Fusarium lateritium SSF2 Induces Autophagic and Apoptosis Cell Death in MCF-7 Breast Cancer Cells
- Authors
- Lee, Dahae; Shim, Sanghee; Kang, Kisung
- Issue Date
- Jun-2021
- Publisher
- MDPI
- Keywords
- Apoptosis; Autophagy; Fusarium lateritium SSF2; MCF-7
- Citation
- Biomolecules, v.11, no.6
- Journal Title
- Biomolecules
- Volume
- 11
- Number
- 6
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/81627
- DOI
- 10.3390/biom11060869
- ISSN
- 2218-273X
- Abstract
- Previous studies have reported that 4,6′-Anhydrooxysporidinone (SSF2-2), isolated from Fusarium lateritium SSF2, has neuroprotective effects on the HT-22 hippocampal neuronal cell line. However, the anti-cancer effect of SSF2-2 remains unclear. Here, we examined the viability of MCF-7 human breast cancer cells treated with SSF2-2 or left untreated using a cell viability assay kit. The underlying molecular mechanism was further investigated by Western blotting and immunocy-tochemistry studies. The results demonstrated that SSF2-2 inhibited the viability of MCF-7 cells. Treatment with SSF2-2 increased the levels of cleaved caspase-9, cleaved caspase-7, poly (ADP-ribose) polymerase (PARP), and LC3B. Additionally, SSF2-2 significantly increased the conversion of LC3-I to LC3II and LC3-positive puncta in MCF-7 cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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