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Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Reg-ulations for Neuropsychiatric Disorders
- Authors
- Singh, D.D.; Verma, R.; Parimoo, P.; Sahu, A.; Kumar, V.; Upadhyay, E.; Yadav, D.K.
- Issue Date
- Mar-2021
- Publisher
- Bentham Science Publishers
- Keywords
- CRISPR/Cas9; Epigenetic regulations; Gene editing; Neuronal development; Neuropsychiatric Disorders; Therapeutic applications; Transcription factor
- Citation
- Current Topics in Medicinal Chemistry, v.21, no.10, pp.878 - 894
- Journal Title
- Current Topics in Medicinal Chemistry
- Volume
- 21
- Number
- 10
- Start Page
- 878
- End Page
- 894
- ISSN
- 1568-0266
- Abstract
- Brain function activity is regulated by several mechanisms of genetic and epigenetic fac-tors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palin-dromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities. © 2021 Bentham Science Publishers.
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Related Researcher
- Yadav, Dharmendra Kumar
- Pharmacy (Department of Biologics)