Lysed and disrupted Bifidobacterium bifidum BGN4 cells promote anti-inflammatory activities in lipopolysaccharide-stimulated RAW 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Nayeon | - |
dc.contributor.author | Lee, Soomin | - |
dc.contributor.author | Jang, Se-Won | - |
dc.contributor.author | Shin, Hee Soon | - |
dc.contributor.author | Park, Jong-Hyun | - |
dc.contributor.author | Park, Myeong Soo | - |
dc.contributor.author | Lee, Byung-Hoo | - |
dc.date.accessioned | 2021-09-02T02:40:36Z | - |
dc.date.available | 2021-09-02T02:40:36Z | - |
dc.date.created | 2021-06-08 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1319-562X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82012 | - |
dc.description.abstract | Bifidobacterium bifidum BGN4 has been shown to improve the immune system by regulating interleukin (IL)-6 in RAW 264.7 macrophage cells. In this study, the dead cells of B. bifidum BGN4 were produced by enzymatic and physical processing to enhance the inhibition properties of pro-inflammatory cytokines using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Notably, the secretion levels of cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α were decreased by the cell-wall disrupted extracts compared to heat-killed cells. The result suggests that the exposed interior-surface of B. bifidum BGN4 has a potential ability to regulate the immune-responses in the gastrointestinal tract due to major substances in inside-cell wall such as peptidoglycan and teichoic acids. In conclusion, the lysed and disrupted cells from the inside out of B. bifidum BGN4 have anti-inflammatory properties as paraprobiotic agents to control chronic inflammatory related-diseases. © 2021 The Authors | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | Saudi Journal of Biological Sciences | - |
dc.title | Lysed and disrupted Bifidobacterium bifidum BGN4 cells promote anti-inflammatory activities in lipopolysaccharide-stimulated RAW 264.7 cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000687307300011 | - |
dc.identifier.doi | 10.1016/j.sjbs.2021.05.028 | - |
dc.identifier.bibliographicCitation | Saudi Journal of Biological Sciences, v.28, no.9, pp.5115 - 5118 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85106970714 | - |
dc.citation.endPage | 5118 | - |
dc.citation.startPage | 5115 | - |
dc.citation.title | Saudi Journal of Biological Sciences | - |
dc.citation.volume | 28 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Lee, Nayeon | - |
dc.contributor.affiliatedAuthor | Lee, Soomin | - |
dc.contributor.affiliatedAuthor | Jang, Se-Won | - |
dc.contributor.affiliatedAuthor | Park, Jong-Hyun | - |
dc.contributor.affiliatedAuthor | Lee, Byung-Hoo | - |
dc.type.docType | Article in Press | - |
dc.subject.keywordAuthor | Anti-inflammation | - |
dc.subject.keywordAuthor | Bifidobacterium bifidum BGN4 | - |
dc.subject.keywordAuthor | Immunoregulatory | - |
dc.subject.keywordAuthor | Paraprobiotic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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