Lysed and disrupted Bifidobacterium bifidum BGN4 cells promote anti-inflammatory activities in lipopolysaccharide-stimulated RAW 264.7 cells
- Authors
- Lee, Nayeon; Lee, Soomin; Jang, Se-Won; Shin, Hee Soon; Park, Jong-Hyun; Park, Myeong Soo; Lee, Byung-Hoo
- Issue Date
- Sep-2021
- Publisher
- ELSEVIER
- Keywords
- Anti-inflammation; Bifidobacterium bifidum BGN4; Immunoregulatory; Paraprobiotic
- Citation
- Saudi Journal of Biological Sciences, v.28, no.9, pp.5115 - 5118
- Journal Title
- Saudi Journal of Biological Sciences
- Volume
- 28
- Number
- 9
- Start Page
- 5115
- End Page
- 5118
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82012
- DOI
- 10.1016/j.sjbs.2021.05.028
- ISSN
- 1319-562X
- Abstract
- Bifidobacterium bifidum BGN4 has been shown to improve the immune system by regulating interleukin (IL)-6 in RAW 264.7 macrophage cells. In this study, the dead cells of B. bifidum BGN4 were produced by enzymatic and physical processing to enhance the inhibition properties of pro-inflammatory cytokines using lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Notably, the secretion levels of cytokines such as interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α were decreased by the cell-wall disrupted extracts compared to heat-killed cells. The result suggests that the exposed interior-surface of B. bifidum BGN4 has a potential ability to regulate the immune-responses in the gastrointestinal tract due to major substances in inside-cell wall such as peptidoglycan and teichoic acids. In conclusion, the lysed and disrupted cells from the inside out of B. bifidum BGN4 have anti-inflammatory properties as paraprobiotic agents to control chronic inflammatory related-diseases. © 2021 The Authors
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