Composition analysis and oral administered effects on dextran sulfate sodium-induced colitis of galactooligosaccharides bioconverted by Bacillus circulans
DC Field | Value | Language |
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dc.contributor.author | Park, Hye-Ryung | - |
dc.contributor.author | Eom, Dong Hyun | - |
dc.contributor.author | Kim, Jae Hwan | - |
dc.contributor.author | Shin, Jung-Cheul | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Shin, Kwang-Soon | - |
dc.date.accessioned | 2021-09-03T02:40:22Z | - |
dc.date.available | 2021-09-03T02:40:22Z | - |
dc.date.created | 2021-07-12 | - |
dc.date.issued | 2021-10-15 | - |
dc.identifier.issn | 0144-8617 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82014 | - |
dc.description.abstract | Galactooligosaccharides have been known to have many health benefits as prebiotic ingredients. In this study, we examined the anti-inflammatory activity of the galactooligosaccharide, NeoGOS-P70 (Korean commercial product), in a dextran sodium sulfate-induced colitis model. Next, we performed compositional characterization of NeoGOS-P70, which confirmed that it was a 77.4% high-purity GOS products, including a large amount of 4′-galactosyllactose. Further experiments in DSS-induced colitis model showed that oral administration of NeoGOS-P70 could significantly improve DSS-induced colitis symptoms, such as weight loss, reduction in colon shortening, and suppression of inflammatory mediators, including interleukin-6, tumor necrosis factor-α, and myeloperoxidase secretion from colon of ulcerative colitis mice. Histological analysis of mucin expression in colon tissue revealed the protective effects of NeoGOS-P70. These results suggest the potential of the novel GOS, NeoGOS-P70, as an anti-ulcerative colitis agent that could regulate inflammatory responses. © 2021 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | Carbohydrate Polymers | - |
dc.title | Composition analysis and oral administered effects on dextran sulfate sodium-induced colitis of galactooligosaccharides bioconverted by Bacillus circulans | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000689203400006 | - |
dc.identifier.doi | 10.1016/j.carbpol.2021.118389 | - |
dc.identifier.bibliographicCitation | Carbohydrate Polymers, v.270 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85109168932 | - |
dc.citation.title | Carbohydrate Polymers | - |
dc.citation.volume | 270 | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 4′-Galactosyllactose | - |
dc.subject.keywordAuthor | Bacillus circulans | - |
dc.subject.keywordAuthor | Galactooligosaccharides | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Ulcerative colitis | - |
dc.subject.keywordPlus | Bacteriology | - |
dc.subject.keywordPlus | Cell death | - |
dc.subject.keywordPlus | Dextran | - |
dc.subject.keywordPlus | Mammals | - |
dc.subject.keywordPlus | Sodium sulfate | - |
dc.subject.keywordPlus | Sulfur compounds | - |
dc.subject.keywordPlus | 4′-galactosyllactose | - |
dc.subject.keywordPlus | Anti-inflammatory activity | - |
dc.subject.keywordPlus | Bacillus circulans | - |
dc.subject.keywordPlus | Commercial products | - |
dc.subject.keywordPlus | Composition analysis | - |
dc.subject.keywordPlus | Dextran sulfate sodium | - |
dc.subject.keywordPlus | Galacto-oligosaccharides | - |
dc.subject.keywordPlus | Health benefits | - |
dc.subject.keywordPlus | Prebiotics | - |
dc.subject.keywordPlus | Ulcerative colitis | - |
dc.subject.keywordPlus | Diseases | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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