Composition analysis and oral administered effects on dextran sulfate sodium-induced colitis of galactooligosaccharides bioconverted by Bacillus circulans
- Authors
- Park, Hye-Ryung; Eom, Dong Hyun; Kim, Jae Hwan; Shin, Jung-Cheul; Shin, Myoung-Sook; Shin, Kwang-Soon
- Issue Date
- 15-Oct-2021
- Publisher
- ELSEVIER SCI LTD
- Keywords
- 4′-Galactosyllactose; Bacillus circulans; Galactooligosaccharides; Inflammation; Ulcerative colitis
- Citation
- Carbohydrate Polymers, v.270
- Journal Title
- Carbohydrate Polymers
- Volume
- 270
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82014
- DOI
- 10.1016/j.carbpol.2021.118389
- ISSN
- 0144-8617
- Abstract
- Galactooligosaccharides have been known to have many health benefits as prebiotic ingredients. In this study, we examined the anti-inflammatory activity of the galactooligosaccharide, NeoGOS-P70 (Korean commercial product), in a dextran sodium sulfate-induced colitis model. Next, we performed compositional characterization of NeoGOS-P70, which confirmed that it was a 77.4% high-purity GOS products, including a large amount of 4′-galactosyllactose. Further experiments in DSS-induced colitis model showed that oral administration of NeoGOS-P70 could significantly improve DSS-induced colitis symptoms, such as weight loss, reduction in colon shortening, and suppression of inflammatory mediators, including interleukin-6, tumor necrosis factor-α, and myeloperoxidase secretion from colon of ulcerative colitis mice. Histological analysis of mucin expression in colon tissue revealed the protective effects of NeoGOS-P70. These results suggest the potential of the novel GOS, NeoGOS-P70, as an anti-ulcerative colitis agent that could regulate inflammatory responses. © 2021 Elsevier Ltd
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