Metabolite analysis in the type 1 diabetic mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박성진 | - |
dc.date.accessioned | 2021-09-20T06:40:17Z | - |
dc.date.available | 2021-09-20T06:40:17Z | - |
dc.date.created | 2021-09-20 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1226-6531 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82177 | - |
dc.description.abstract | Type 1 diabetes mellitus (T1DM) is caused by insufficient production of insulin, which is involved in carbohydrate metabolism. Type 2 diabetes mellitus (T2DM) has insulin resistance in which cells do not respond adequately to insulin. The purpose of this study was to estimate the characteristics of type 1 diabetes using streptozotocin-treated mice (STZ-mouse). The sera samples were collected from the models of hyperglycemic mouse and healthy mouse. Based on the pair-wise comparison, five metabolites were found to be noticeable: glucose, malonic acid, 3-hyroxybutyrate, methanol, and tryptophan. It was very natural glucose was upregulated in STZ-mouse. 3-hyroxybutyrate was also increased in the model. However, malonic acid, tryptophan, and methanol was downregulated in STZ-mouse. Several metabolites acetoacetate, acetone, alanine, arginine, asparagine, histidine, lysine, malate, methionine, ornithine, proline, propylene glycol, threonine, tyrosine, and urea tended to be varied in STZ-mouse while the statistical significance was not stratified for the variation. The multivariate model of PCA clearly showed the group separation between healthy control and STZ-mouse. The most significant metabolites that contributed the group separation included glucose, citrate, ascorbate, and lactate. Lactate did not show the statistical significance of change in t-test while it tends to down-regulated both in DNP and Diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국자기공명학회 | - |
dc.relation.isPartOf | Journal of the Korean Magnetic Resonance Society | - |
dc.title | Metabolite analysis in the type 1 diabetic mouse model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.wosid | 000730483500001 | - |
dc.identifier.doi | 10.6564/JKMRS.2021.25.3.033 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Magnetic Resonance Society, v.25, no.3, pp.33 - 38 | - |
dc.identifier.kciid | ART002755553 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 38 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | Journal of the Korean Magnetic Resonance Society | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 박성진 | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Type I | - |
dc.subject.keywordAuthor | Metabolite | - |
dc.subject.keywordAuthor | NMR | - |
dc.subject.keywordAuthor | Streptozotocin | - |
dc.description.journalRegisteredClass | kci | - |
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