Metabolite analysis in the type 1 diabetic mouse model
- Authors
- 박성진
- Issue Date
- Sep-2021
- Publisher
- 한국자기공명학회
- Keywords
- Diabetes; Type I; Metabolite; NMR; Streptozotocin
- Citation
- Journal of the Korean Magnetic Resonance Society, v.25, no.3, pp.33 - 38
- Journal Title
- Journal of the Korean Magnetic Resonance Society
- Volume
- 25
- Number
- 3
- Start Page
- 33
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82177
- DOI
- 10.6564/JKMRS.2021.25.3.033
- ISSN
- 1226-6531
- Abstract
- Type 1 diabetes mellitus (T1DM) is caused by insufficient production of insulin, which is involved in carbohydrate metabolism. Type 2 diabetes mellitus (T2DM) has insulin resistance in which cells do not respond adequately to insulin. The purpose of this study was to estimate the characteristics of type 1 diabetes using streptozotocin-treated mice (STZ-mouse). The sera samples were collected from the models of hyperglycemic mouse and healthy mouse. Based on the pair-wise comparison, five metabolites were found to be noticeable: glucose, malonic acid, 3-hyroxybutyrate, methanol, and tryptophan. It was very natural glucose was upregulated in STZ-mouse. 3-hyroxybutyrate was also increased in the model. However, malonic acid, tryptophan, and methanol was downregulated in STZ-mouse. Several metabolites acetoacetate, acetone, alanine, arginine, asparagine, histidine, lysine, malate, methionine, ornithine, proline, propylene glycol, threonine, tyrosine, and urea tended to be varied in STZ-mouse while the statistical significance was not stratified for the variation. The multivariate model of PCA clearly showed the group separation between healthy control and STZ-mouse. The most significant metabolites that contributed the group separation included glucose, citrate, ascorbate, and lactate. Lactate did not show the statistical significance of change in t-test while it tends to down-regulated both in DNP and Diabetes.
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