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Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract

Authors
Hien Thi HoangVinh Van TranVu Khac Hoang BuiKwon, Oh-HyeokMoon, Ju-YoungLee, Young-Chul
Issue Date
Sep-2021
Publisher
Nature Research
Citation
Scientific Reports, v.11, no.1
Journal Title
Scientific Reports
Volume
11
Number
1
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82179
DOI
10.1038/s41598-021-97363-8
ISSN
2045-2322
Abstract
The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity, moisturizing effect, and clinical skin irritation of the hand gel are evaluated. The hand gel with 0.5 wt.% ZnAC and 1.0 v/v% O. humifusa extract can kill more than 99% Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria) after 24 h. Toxicity evaluation shows that, the hand gel does not affect the viability of mammalian HaCaT cells. Additionally, skin moisture is increased by applying the hand gel while its viscosity is at the standard level of commercial products. The hand gel has a skin irritation index of 0.0 and is classified as a non-irritating product. We successfully formulated hand gel from ZnAC, glucomannan, glycerol, and O. humifusa extract. Owing to the high antimicrobial activity and skin protection of hand gels, they are suitable to be used as hand sanitizers in restaurants, hospitals, and homes effectively. © 2021, The Author(s).
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