Detailed Information
Cited 7 time in 
Cited 8 time in 
Cited 8 time in
Metadata Downloads
Drug resistance reversal potential of multifunctional thieno[3,2-c]pyran via potentiation of antibiotics in MDR P. aeruginosa
- Authors
- Dwivedi, G.R.; Rai, R.; Pratap, R.; Singh, K.; Pati, S.; Sahu, S.N.; Kant, R.; Darokar, M.P.; Yadav, D.K.
- Issue Date
- Oct-2021
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- 2-c]pyran-2-ones; Biofilm synthesis; Drug resistance reversal; Efflux pump inhibition; Synthetic compounds; Thieno[3
- Citation
- BIOMEDICINE & PHARMACOTHERAPY, v.142
- Journal Title
- BIOMEDICINE & PHARMACOTHERAPY
- Volume
- 142
- ISSN
- 0753-3322
- Abstract
- We explored the antibacterial potential (alone and combination) against multidrug resistant (MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized thieno[3,2-c]pyran-2-ones in combination with different antibiotics. Out of 14 compounds, two compounds (3g and 3l) abridged the MIC of tetracycline (TET) by 16 folds. Compounds was killing the KG-P2 cells, in time dependent manner, lengthened post-antibiotic effect (PAE) of TET and found decreased the mutant prevention concentration (MPC) of TET. In ethidium bromide efflux experiment, two compounds repressed the drug transporter (efflux pumps) which is further supported by molecular docking of these compounds with efflux complex MexAB-OprM. In another study, these compounds inhibited the synthesis of biofilm. © 2021 The Authors
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Yadav, Dharmendra Kumar
- Pharmacy (Department of Biologics)