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Medical Manuscript: Serum Total Testosterone as a Prognostic Indicator in Male Patients With Terminal Cancer
- Issue Date
- Jun-2016
- Publisher
- SAGE PUBLICATIONS INC
- Keywords
- palliative care; prognostication; serum testosterone
- Citation
- AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE, v.33, no.5, pp.483 - 488
- Journal Title
- AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
- Volume
- 33
- Number
- 5
- Start Page
- 483
- End Page
- 488
- ISSN
- 1049-9091
- Abstract
- The role of total serum testosterone in the prognosis of terminal cancer is unclear. We retrospectively investigated the total serum testosterone level in 69 male patients with terminal cancer in a palliative care unit. The association between the serum testosterone level and survival was assessed using Cox proportional hazard model. The median value of serum total testosterone was 44.5 ng/dL, far lower than previously reported in patients with advanced cancer. Multivariate analysis revealed thrombocytopenia (adjusted hazard ratio [aHR], 2.68), hypoalbuminemia (aHR, 2.02), azotemia (aHR, 2.67), and lower serum testosterone level (aHR, 2.03) were significantly negatively prognostic of survival. Lower serum testosterone level was an independent unfavorable prognostic factor for life expectancy in male patients with terminal cancer.
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Related Researcher
- Hwang, In Cheol
- College of Medicine (Department of Medicine)