Prospective role of N-acetyl-5-methoxytryptamine and 5-hydroxytryptophan in β-cell health and improved insulin sensitivity in hyperglycemia
- Authors
- Raghav, A.; Mishra, B.K.; Tomar, R.; Raghav, S.; Jeong, G.-B.
- Issue Date
- Mar-2021
- Publisher
- Korean Society of Sleep Medicine
- Keywords
- 5-hydroxytryptophan; Hyperglycemia; Insulin; N-acetyl-5-methoxytryptamine
- Citation
- Chronobiology in Medicine, v.3, no.1, pp.4 - 7
- Journal Title
- Chronobiology in Medicine
- Volume
- 3
- Number
- 1
- Start Page
- 4
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82346
- DOI
- 10.33069/cim.2021.0001
- ISSN
- 2635-9162
- Abstract
- Melatonin and serotonin are considered to be the important neurotransmitter and prime hormones responsible for the body homeostasis. The melatonin exert its effect on insulin signaling through melatonin receptors (MT-1 and MT-2). Similarly, 5-hydroxytryptophan, also plays an important role in insulin secretion, β-cells function thereby contributing an important role in diabetes management. Several animals and clinical studies suggested that supplementation of N-acetyl-5-methoxytryptamine and 5-hydroxytryptophan improves the insulin release from the β-cells of the pancreas and can be used as prospective therapy in management of diabetes and its associated complications. Copyright © 2021 Korean Academy of Sleep Medicine
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