Prospective role of N-acetyl-5-methoxytryptamine and 5-hydroxytryptophan in β-cell health and improved insulin sensitivity in hyperglycemia

Abstract

Melatonin and serotonin are considered to be the important neurotransmitter and prime hormones responsible for the body homeostasis. The melatonin exert its effect on insulin signaling through melatonin receptors (MT-1 and MT-2). Similarly, 5-hydroxytryptophan, also plays an important role in insulin secretion, β-cells function thereby contributing an important role in diabetes management. Several animals and clinical studies suggested that supplementation of N-acetyl-5-methoxytryptamine and 5-hydroxytryptophan improves the insulin release from the β-cells of the pancreas and can be used as prospective therapy in management of diabetes and its associated complications. Copyright © 2021 Korean Academy of Sleep Medicine