카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과
DC Field | Value | Language |
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dc.contributor.author | Sym, Eunjin | - |
dc.contributor.author | Shim, Won Sik | - |
dc.date.accessioned | 2021-10-14T03:40:14Z | - |
dc.date.available | 2021-10-14T03:40:14Z | - |
dc.date.created | 2021-10-14 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0377-9556 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82376 | - |
dc.description.abstract | Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality oflife. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety andefficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) − an endogenous lipid with a putative antinociceptiveeffect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system,which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselectivecation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentiallysafe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, andthe function of AA-5-HT in pain modulation. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한약학회 | - |
dc.relation.isPartOf | 약 학 회 지 | - |
dc.title | 카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과 | - |
dc.title.alternative | Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.doi | 10.17480/psk.2021.65.4.237 | - |
dc.identifier.bibliographicCitation | 약 학 회 지, v.65, no.4, pp.237 - 245 | - |
dc.identifier.kciid | ART002754110 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 245 | - |
dc.citation.startPage | 237 | - |
dc.citation.title | 약 학 회 지 | - |
dc.citation.volume | 65 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Shim, Won Sik | - |
dc.subject.keywordAuthor | GPR119 agonists | - |
dc.subject.keywordAuthor | Antidiabetic agents | - |
dc.subject.keywordAuthor | Fragment structure | - |
dc.subject.keywordAuthor | Bioequivalent | - |
dc.subject.keywordAuthor | Pyridazine analogs | - |
dc.subject.keywordAuthor | Lead compounds | - |
dc.description.journalRegisteredClass | kci | - |
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