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카나비노이드 수용체 활성화 및 TRPV1 억제를 통한 arachidonoyl-serotonin (AA-5-HT)의 진통 효과Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1
- Other Titles
- Antinociceptive Effects of Arachidonoyl-serotonin (AA-5-HT) by Activation of Cannabinoid Receptor and Inhibition of TRPV1
- Authors
- Sym, Eunjin; Shim, Won Sik
- Issue Date
- Aug-2021
- Publisher
- 대한약학회
- Keywords
- GPR119 agonists; Antidiabetic agents; Fragment structure; Bioequivalent; Pyridazine analogs; Lead compounds
- Citation
- 약 학 회 지, v.65, no.4, pp.237 - 245
- Journal Title
- 약 학 회 지
- Volume
- 65
- Number
- 4
- Start Page
- 237
- End Page
- 245
- ISSN
- 0377-9556
- Abstract
- Pain is a noxious sensation caused by tissue damage, which can severely interfere with a person’s quality oflife. Although numerous analgesics are available for eradicating pain, there remain limitations in terms of safety andefficacy. This review focuses on arachidonoyl-serotonin (AA-5-HT) − an endogenous lipid with a putative antinociceptiveeffect. After detailed investigation, previous studies have revealed that AA-5-HT can stimulate the cannabinoid system,which results in the inhibition of pain sensation. Moreover, AA-5-HT can inhibit the action of TRPV1, which is a nonselectivecation channel that mediates pain signals in the nervous system. This dual effect makes AA-5-HT a potentiallysafe and potent analgesic. This review summarizes the roles of the cannabinoid system and TRPV1 in pain sensation, andthe function of AA-5-HT in pain modulation.
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Related Researcher
- Shim, Won-Sik
- Pharmacy (Dept.of Pharmacy)