Antifungal Effect of Chitosan as Ca2+ Channel Blocker
- Authors
- Lee, Choon Geun; Koo, Ja Choon; Park, Jae Kweon
- Issue Date
- Jun-2016
- Publisher
- KOREAN SOC PLANT PATHOLOGY
- Keywords
- antifungal activity; Ca2+ channel; chitosan; molecular weight; Penicillium italicum
- Citation
- PLANT PATHOLOGY JOURNAL, v.32, no.3, pp.242 - 250
- Journal Title
- PLANT PATHOLOGY JOURNAL
- Volume
- 32
- Number
- 3
- Start Page
- 242
- End Page
- 250
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8247
- DOI
- 10.5423/PPJ.OA.08.2015.0162
- ISSN
- 1598-2254
- Abstract
- The aim of this study was to investigate antifungal activity of a range of different molecular weight (MW) chitosan against Penicillium italicum. Our results demonstrate that the antifungal activity was dependent both the MW and concentration of the chitosan. Among a series of chitosan derived from the hydrolysis of high MW chitosan, the fractions containing various sizes of chitosan ranging from 3 to 15 glucosamine units named as chitooligomers-F2 (CO-F2) was found to show the highest antifungal activity against P. italicum. Furthermore, the effect of CO-F2 toward this fungus was significantly reduced in the presence of Ca2+, whereas its effect was recovered by ethylenediaminetetraacetic acid, suggesting that the CO-F2 acts via disruption of Ca2+ gradient required for survival of the fungus. Our results suggest that CO-F2 may serve as potential compounds to develop alternatives to synthetic fungicides for the control of the postharvest diseases.
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