Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics Approach
- Authors
- Mohammad, T.; Choudhury, A.; Habib, I.; Asrani, P.; Mathur, Y.; Umair, M.; Anjum, F.; Shafie, A.; Yadav, D.K.; Hassan, M.I.
- Issue Date
- Oct-2021
- Publisher
- Frontiers Media S.A.
- Keywords
- coronavirus disease 2019; SARS-CoV-2 mutations; SARS-CoV-2 pathogenesis; severe acute respiratory syndrome coronavirus-2; single amino acid substitutions
- Citation
- Frontiers in Cellular and Infection Microbiology, v.11
- Journal Title
- Frontiers in Cellular and Infection Microbiology
- Volume
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82666
- DOI
- 10.3389/fcimb.2021.765039
- ISSN
- 2235-2988
- Abstract
- A continual rise in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection causing coronavirus disease (COVID-19) has become a global threat. The main problem comes when SARS-CoV-2 gets mutated with the rising infection and becomes more lethal for humankind than ever. Mutations in the structural proteins of SARS-CoV-2, i.e., the spike surface glycoprotein (S), envelope (E), membrane (M) and nucleocapsid (N), and replication machinery enzymes, i.e., main protease (Mpro) and RNA-dependent RNA polymerase (RdRp) creating more complexities towards pathogenesis and the available COVID-19 therapeutic strategies. This study analyzes how a minimal variation in these enzymes, especially in S protein at the genomic/proteomic level, affects pathogenesis. The structural variations are discussed in light of the failure of small molecule development in COVID-19 therapeutic strategies. We have performed in-depth sequence- and structure-based analyses of these proteins to get deeper insights into the mechanism of pathogenesis, structure-function relationships, and development of modern therapeutic approaches. Structural and functional consequences of the selected mutations on these proteins and their association with SARS-CoV-2 virulency and human health are discussed in detail in the light of our comparative genomics analysis. © Copyright © 2021 Mohammad, Choudhury, Habib, Asrani, Mathur, Umair, Anjum, Shafie, Yadav and Hassan.
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