A Tubular Biomaterial Construct Exhibiting a Negative Poisson's Ratio
- Authors
- Lee, Jin Woo; Soman, Pranav; Park, Jeong Hun; Chen, Shaochen; Cho, Dong-Woo
- Issue Date
- 27-May-2016
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.11, no.5
- Journal Title
- PLOS ONE
- Volume
- 11
- Number
- 5
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8277
- DOI
- 10.1371/journal.pone.0155681
- ISSN
- 1932-6203
- Abstract
- Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson's ratio v(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson's ratios of -0.6 <= -v(xy) <= -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive v(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.
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