A new alpha-pyrone from Arthrinium pseudosinense culture medium and its estrogenic activity in MCF-7 cells
- Authors
- Kwon, Haeun; Nguyen, Quynh Nhu; Na, Myung Woo; Kim, Ki Hyun; Guo, Yuanqiang; Yim, Joung Han; Shim, Sang Hee; Kim, Jae-Jin; Kang, Ki Sung; Lee, Dongho
- Issue Date
- Dec-2021
- Publisher
- SPRINGERNATURE
- Citation
- JOURNAL OF ANTIBIOTICS, v.74, no.12, pp.893 - 897
- Journal Title
- JOURNAL OF ANTIBIOTICS
- Volume
- 74
- Number
- 12
- Start Page
- 893
- End Page
- 897
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82826
- DOI
- 10.1038/s41429-021-00473-8
- ISSN
- 0021-8820
- Abstract
- A new alpha-pyrone analog, arthrifuranone A (1) was isolated from an EtOAc-extract of Arthrinium pseudosinense culture medium. The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using MS and NMR spectroscopic techniques, and the absolute configuration was established by the Mosher's method and gauge-including atomic orbital NMR chemical shift calculations, followed by DP4 + analysis. The isolated compound was evaluated for its estrogenic activity using the MCF-7 estrogen responsive human breast cancer cells. Compound 1 showed estrogenic activity by increasing the proliferation of MCF-7 cells at the concentration of 3.125 mu M via phosphorylation of estrogen receptor-alpha. [GRAPHICS]
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Collections - 한의과대학 > 한의예과 > 1. Journal Articles
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