Synthesis of fluorescent silicon quantum dots for ultra-rapid and selective sensing of Cr(VI) ion and biomonitoring of cancer cells
- Authors
- Le Minh Tu Phan; Baek, Seung Hoon; Thang Phan Nguyen; Park, Kyoung Yeol; Ha, Siyoung; Rafique, Rafia; Kailasa, Suresh Kumar; Park, Tae Jung
- Issue Date
- Dec-2018
- Publisher
- ELSEVIER
- Keywords
- Si QDs; Cr(VI) detection; Cell imaging; Fluorescence quenching; Water samples
- Citation
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, v.93, pp.429 - 436
- Journal Title
- MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
- Volume
- 93
- Start Page
- 429
- End Page
- 436
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/82875
- DOI
- 10.1016/j.msec.2018.08.024
- ISSN
- 0928-4931
- Abstract
- A facile one-step synthetic approach was developed for fabrication of fluorescent silicon quantum dots (Si QDs) and used as a probe for fluorescence detection of hexavalent chromium (Cr (VI)) in environmental water samples. The as-prepared Si QDs exhibit a strong fluorescence emission peak at 520 nm with a quantum yield of 14.2%. The fluorescent Si QDs were rapidly produced by using ascorbic acid as a reductant at 55 degrees C. The emission peak of Si QDs at 420 nm was effectively quenched upon the addition of Cr(VI). The Si QDs acted as the best fluorescent probe for the detection of Cr(VI) at PBS pH 7.4. The developed probe possessed a good linear correlation (R-2 = 0.992) between Cr(VI) concentration (1.25-40 mu M) and the (F-o-F)/F-o values with a detection limit of 0.65 mu M. Furthermore, the Si QDs served as a bio-probe for fluorescence imaging of A549 lung cancer cells and cell viability results confirmed the good biocompatible nature of Si QDs. The as-fabricated Si QDs show several advantages such as rapidity, selectivity and biocompatibility for sensing of Cr(VI) and imaging of A549 cells, which opens a facile analytical platform for environmental and bioimaging applications.
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