Lactiplantibacillusplantarum ATG-K2 Exerts an Anti-Obesity Effect in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiome
- Authors
- Lee, Young-Sil; Park, Eun-Jung; Park, Gun-Seok; Ko, Seung-Hyun; Park, Juyi; Lee, You-Kyung; Kim, Jong-Yeon; Lee, Daeyoung; Kang, Jihee; Lee, Hae-Jeung
- Issue Date
- Dec-2021
- Publisher
- MDPI
- Keywords
- Gut microbiome; Lactiplantibacillus plantarum ATG-K2; Lipid metabolism; Obesity; Probiotics; Short-chain fatty acids
- Citation
- International Journal of Molecular Sciences, v.22, no.23
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 22
- Number
- 23
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83124
- DOI
- 10.3390/ijms222312665
- ISSN
- 1661-6596
- Abstract
- Obesity is a major health problem. Compelling evidence supports the beneficial effects of probiotics on obesity. However, the anti-obesity effect of probiotics remains unknown. In this study, we investigated the anti-obesity effects and potential mechanisms of Lactiplantibacillus plantarum ATG-K2 using 3T3-L1 adipocytes and high-fat diet (HFD)-induced obese mice. 3T3-L1 cells were incubated to determine the effect of lipid accumulation with lysate of L. plantarum ATG-K2. Mice were fed a normal fat diet or HFD with L. plantarum ATG-K2 and Orlistat for 8 weeks. L. plantarum ATG-K2 inhibited lipid accumulation in 3T3-L1 adipocytes, and reduced body weight gain, WAT weight, and adipocyte size in HFD-induced obese mice, concurrently with the downregulation of PPARγ, SREBP1c, and FAS and upregulation of PPARα, CTP1, UCP1, Prdm16, and ND5. Moreover, L. plantarum ATG-K2 decreased TG, T-CHO, leptin, and TNF-α levels in the serum, with corre-sponding gene expression levels in the intestine. L. plantarum ATG-K2 modulated the gut microbi-ome by increasing the abundance of the Lactobacillaceae family, which increased SCFA levels and branched SCFAs in the feces. L. plantarum ATG-K2 exhibited an anti-obesity effect and anti-hyper-lipidemic effect in 3T3-L1 adipocytes and HFD-induced obese mice by alleviating the inflammatory response and regulating lipid metabolism, which may be influenced by modulation of the gut microbiome and its metabolites. Therefore, L. plantarum ATG-K2 can be a preventive and therapeutic agent for obesity. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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