SARS-CoV-2: Emergence of New Variants and Effectiveness of Vaccines
- Authors
- Singh, D.D.; Parveen, A.; Yadav, D.K.
- Issue Date
- Dec-2021
- Publisher
- Frontiers Media S.A.
- Keywords
- infectivity; neutralization; SARS-CoV-2; vaccine; variant
- Citation
- Frontiers in Cellular and Infection Microbiology, v.11
- Journal Title
- Frontiers in Cellular and Infection Microbiology
- Volume
- 11
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83226
- DOI
- 10.3389/fcimb.2021.777212
- ISSN
- 2235-2988
- Abstract
- The emergence of SARS-CoV-2 variants may cause resistance at the immunity level against current vaccines. Some emergent new variants have increased transmissibility, infectivity, hospitalization, and mortality. Since the administration of the first SARS-CoV-2 vaccine to a human in March 2020, there is an ongoing global race against SARS-CoV-2 to control the current pandemic situation. Spike (S) glycoprotein of SARS-CoV-2 is the main target for current vaccine development, which can neutralize the infection. Companies and academic institutions have developed vaccines based on the S glycoprotein, as well as its antigenic domains and epitopes, which have been proven effective in generating neutralizing antibodies. The effectiveness of SARS-CoV-2 vaccines and other therapeutics developments are limited by the new emergent variants at the global level. We have discussed the emergent variants of SARS-CoV-2 on the efficacy of developed vaccines. Presently, most of the vaccines have been tremendously effective in severe diseases. However, there are still noteworthy challenges in certifying impartial vaccines; the stories of re-infections are generating more stressful conditions, and this needs further clinical evaluation. Copyright © 2021 Singh, Parveen and Yadav.
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