Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.
- Authors
- Bae, Munhyung; An, Joon Soo; Bae, Eun Seo; Oh, Jedo; Park, So Hyun; Lim, Yeonjung; Ban, Yeon Hee; Kwon, Yun; Cho, Jang-Cheon; Yoon, Yeo Joon; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan
- Issue Date
- May-2019
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.21, no.10, pp.3635 - 3639
- Journal Title
- ORGANIC LETTERS
- Volume
- 21
- Number
- 10
- Start Page
- 3635
- End Page
- 3639
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83303
- DOI
- 10.1021/acs.orglett.9b01057
- ISSN
- 1523-7060
- Abstract
- The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.
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