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Mohangic Acids A-E, p-Aminoacetophenonic Acids from a Marine-Mudflat-Derived Streptomyces sp.

Authors
Bae, MunhyungMoon, KyuhoKim, JihyePark, Hyen JooLee, Sang KookShin, JongheonOh, Dong-Chan
Issue Date
Feb-2016
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.79, no.2, pp.332 - 339
Journal Title
JOURNAL OF NATURAL PRODUCTS
Volume
79
Number
2
Start Page
332
End Page
339
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83311
DOI
10.1021/acs.jnatprod.5b00956
ISSN
0163-3864
Abstract
Mohangic acids A-E (1-5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by C-13 NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity.
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