Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
DC Field | Value | Language |
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dc.contributor.author | Bae, Munhyung | - |
dc.contributor.author | Chung, Beomkoo | - |
dc.contributor.author | Oh, Ki-Bong | - |
dc.contributor.author | Shin, Jongheon | - |
dc.contributor.author | Oh, Dong-Chan | - |
dc.date.accessioned | 2022-01-19T06:41:46Z | - |
dc.date.available | 2022-01-19T06:41:46Z | - |
dc.date.created | 2022-01-19 | - |
dc.date.issued | 2015-08 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83312 | - |
dc.description.abstract | Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and -methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.title | Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp. | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000360625700026 | - |
dc.identifier.doi | 10.3390/md13085187 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.13, no.8, pp.5187 - 5200 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84940426144 | - |
dc.citation.endPage | 5200 | - |
dc.citation.startPage | 5187 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Bae, Munhyung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | marine actinomycete | - |
dc.subject.keywordAuthor | secondary metabolite | - |
dc.subject.keywordAuthor | hormaomycin | - |
dc.subject.keywordAuthor | peptide | - |
dc.subject.keywordAuthor | antibiotic | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.subject.keywordPlus | ACTINOMYCETE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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